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BIO 325 - Quiz 4-1 - BLAST...

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BIO 325 (Genetics) Fall 2009 Quiz 4 Maximum points: 25 Due in class on Thursday (Dec 3, 2009) Select 5 disease traits in humans for which gene(s) associated with each trait has been identified (for example, cystic fibrosis is most commonly associated with mutations in the gene for CFTR). DO NOT use cystic fibrosis as one of your traits. For each trait, answer the following questions: 1. The name of the gene and the function of the gene product. 2. Size of the gene and its location (chromosome number and its position on the chromosome). 3. The number of exons and introns and the length of the coding region. 4. Perform a database search to find homologous protein sequences using the
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Unformatted text preview: BLAST program (http://blast.ncbi.nlm.nih.gov/Blast.cgi). List the top 10 sequences for each protein with their known function. 5. Considering that a mutation in the gene results in the disease, how would you treat this disease using gene therapy? Describe briefly the design of your experiments. #1 1. FMR-1 gene codes for fragile X mental retardation protein, or FMRP. The function of the gene product plays a development in the synaptic connections between nerve cells in the brain and helps regulate synapse plasticity, which helps with learning and memory. 2. Chromosome X; 146.8-146.84 Mb 3. 3...
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