Discussion%20qestions%202%20F2009-KEY - Discussion...

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Discussion questions 2 1. Huntington's disease is inherited as an autosomal dominant trait. A woman whose great-grandfather had Huntington's disease marries and is considering having a child. Both her father and grandfather were killed in wars while in their twenties (too young to show disease phenotype). If she consulted you, how would you advise her about the risks to her child? (Make sure you give her probability values for your predictions.) Apparently the father and grandfather did not show symptoms of Huntington's disease, but since it is a late-onset disease, they probably would not have expressed it in their early twenties. There is a 1/2 chance that the grandfather inherited the allele, a 1/2 chance that the father received it from him, a further 1/2 chance that the woman received it, and then a further 1/2 chance that her future child would receive it. The overall chance that the woman's child will develop the disease is 1/2 × 1/2 × 1/2 × 1/2 = 1/16. 2.
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This note was uploaded on 12/17/2009 for the course BIO Genetics taught by Professor Saxena during the Spring '08 term at University of Texas.

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Discussion%20qestions%202%20F2009-KEY - Discussion...

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