lecture18 - LECTURE 18 05 October 2009(P J Hollenbeck...

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Fig 13-1 from ECB LECTURE 18 05 October 2009 (P. J. Hollenbeck) BIOL231 BIOENERGETICS – OVERVIEW & GLYCOLYSIS Read pp. 425-36 DVD: 13.1 <We’ve been looking at how the cell uses energy to create order and do work - where does it come from?> I. OVERVIEW (A) Harvesting the energy in glucose (1) Recall that the reaction: 61 26 2 2 2 glucose (C H O ) + O => CO + H O is hugely favorable. In fact, it has a ) G of approximately ! 2880 kJ/mole glucose! You could burn glucose with a flame (which provides the activation energy) and carry out this reaction all at once, and rather pointlessly. But the cell breaks this reaction up A into many individual steps, most of which have an E that is close to the thermal energy available in the cell: The cell will couple (for the most part rather indirectly) the energy from this favorable reaction to an unfavorable reaction, the synthesis of ATP: i ADP + P => ATP ( ) G approximately +30 kJ/mole) Thus, in a perfectly-designed cell, we could imagine glucose being broken down through a succession of 90 or so coupled reactions, each of which yielded one ATP. But of course the cell does it in a much more complex way than that! (2) In the cell, glucose breakdown proceeds through 4 different STAGES (your text divides it into 3 stages with different meanings), each with many steps, involving many proteins, and each occurring in a particular location in the cell. (B) Stages. We want to know: (1) What are the stages of glucose breakdown, (2) where in the cell does each occur, (3) what kind of coupled reactions are used in each, (3) in what form does each harvest the energy of glucose? Here is a table of that information:
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Fig 13-2 from ECB .
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lecture18 - LECTURE 18 05 October 2009(P J Hollenbeck...

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