2410 -week6

2410 -week6 - 10/22/2009 What do we know about infant...

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10/22/2009 2 Postnatal Brain Development 40 50 60 70 00 m BIRTH ADOLESCENCE 3 o o o o o Regional variation “BLOOMING” & “PRUNING” 0 10 20 30 Synapses/ 1 o o o o o o o o BIRTH 1 5 10 ADULT Age (years) Auditory Cortex Visual Cortex Prefrontal Cortex o Regional variation Compare Visual and Prefrontal (Huttenlocher) VERY LONG POSTNATAL PERIOD OF DEVELOPMENT Postnatal Brain Development from Casey et al. (2006) Postnatal Brain Development Gray & White Matter Postnatal Development Decrease of gray – increase of white Gogtay et al. (2004) PNAS What do you know about brain development and adolescence? What are the implication of the prolonged development of the prefrontal cortex? Postnatal Brain Development White Matter • Decreases in gray matter (neurons) increases in white matter (myelinated axons)
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10/22/2009 3 Methods of Brain Imaging Brain imaging Structural Functional Tools and Methods: PET Tools and Methods: PET • Functional imaging technique • Injection of radioactive, positron emitting agent F ndamental ass mption here there is more • Fundamental assumption: where there is more activity there is also more blood • Where there is more blood flow there will be more radiation and thus more gamma rays Subtraction method • Subtracting activation from rest images – Moving vs. still images – Words vs. no words – Numbers vs. no numbers
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2410 -week6 - 10/22/2009 What do we know about infant...

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