Chapter 19 PPT spring

Chapter 19 PPT spring - Chapter 19: I mmunological disor...

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Unformatted text preview: Chapter 19: I mmunological disor der s Lectur e Hypersensitivities Autoimmune diseases Lab Major unknown Water samples for next class (get collection bottles) Hypersensitivities Type I : anaphylactic reactions Figure 19.1a Sensitization: B cell makes I gE to Ag; I gE binds to mast/ basophil cells Secondary exposure: immediate reaction due to crosslinking of > 1 I gE by Ag on mast cell degranulation Reaction time: minutes Type I I : cytotoxic reactions ABO blood group system Table 19.2 I gG and I gM bind to cell activates complement and macrophage cell death Reaction time: hours Figure 19.4 Type I I : cytotoxic reactions hemolytic disease of newborn Figure 19.5 Type I I : cytotoxic reactions thrombocytopenic purpura Drug (hapten) binds to platelet (or RBC/ WBC) Antibodies are formed complement activation and cell death Type I I I : immune complex reactions Figure 19.6 I mmune reaction against soluble antigens Ratio of antibody to antigen (slight excess of antigen) binding occurs complex sticks into basement membrane of cells triggers inflammation via neutrophils Reaction time: hours Type I V:...
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This note was uploaded on 12/23/2009 for the course BIO 205 taught by Professor Murphy during the Fall '09 term at Miramar College.

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Chapter 19 PPT spring - Chapter 19: I mmunological disor...

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