10-16 - 1 Nucleophilic Substitution Reactions 81 continued...

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Unformatted text preview: 1 Nucleophilic Substitution Reactions 81 continued Substitution Reaction Mechanisms S N 2 C Nu X + C X Nu 82 An alternative reaction mechanism: C Nu fast S N 1 S N 1 = Substitution Nucleophilic 1st Order rate = k ' G C X \ C \ X 83 E R C Nu: \ S N 1 rate = k ' G C X \ C C Nu: \ If we use a more nucleophilic nucleophile, the rate will: 84 E R a. increase b. decrease c. not change Factors affecting S N 1 reaction rate ' G C C X 1. Nucleophilicity (basicity) of the nucleophile. The nucleophilicity of the nucleophile has no effect on the rate of S N 1 reactions 85 E R reactions. Factors affecting S N 1 reaction rate ' G C C X 2. basicity of the leaving group. S N 1 reactions occur f t ith d 1. Nucleophilicity (basicity) of the nucleophile. 86 E R faster with good leaving groups (weak bases). 2 Factors affecting S N 1 reaction rate ' G C C X 2. basicity of the leaving group. 1. basicity (nucleophilicity) of the nucleophile. 3. structure of the substrate 87 E R substrate. 3. structure of the substrate alkyl group substitution in S N 1 reactions C Br H H H C Br H CH 3 H C Br CH 3 CH 3 H C Br CH...
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10-16 - 1 Nucleophilic Substitution Reactions 81 continued...

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