cancer - Printable Flash Cards 12/24/09 1:37 AM Term 1...

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12/24/09 1:37 AM Printable Flash Cards Page 1 of 20 http://www.flashcardmachine.com/print/?topic_id=441312 Term 1 Tumor Suppressor Genes Definition 1 -Control cell growth -Inhibits cell division -Absence allows cell division -Examples: rb, p53, BRCA-1 Term 2 Two-Hit Model Definition 2 -Genes require two nonfunctional genes to become cancerous -Loss of function occurs through inheritance or somatic mutation -Mode of cancer for tumor-supressor genes -Examples: rb, p53, BRCA-1 Term 3 Proto-Oncogenes Definition 3 -Normal cell devision -On promotes cell division -Always present and usually normally function -Areas with more cell division are more at risk
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12/24/09 1:37 AM Printable Flash Cards Page 2 of 20 http://www.flashcardmachine.com/print/?topic_id=441312 Term 4 Oncogenes Definition 4 -Altered proto-oncogene -Examples: erbB, ras, src Term 5 erbB Definition 5 Epidermal growth factor receptor Term 6 ras Definition 6 GTP/GDP binding protein
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12/24/09 1:37 AM Printable Flash Cards Page 3 of 20 http://www.flashcardmachine.com/print/?topic_id=441312 Term 7 src Definition 7 Tyrosine Kinase Term 8 Zeroderma Pigmentosum Definition 8 Skin Cancer -Repair type: Excision repair Term 9 BRCA-1 Definition 9 Familial Breast Cancer -Repair Type: Apparent crosslinking repair function
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12/24/09 1:37 AM Printable Flash Cards Page 4 of 20 http://www.flashcardmachine.com/print/?topic_id=441312 Term 10 Prototroph Definition 10 Wild type of bacterium or fungus that can grow on minimal media. Term 11 Auxotroph Definition 11 Bacterium or fungus that possesses a nutritional mutation that disrupts its ability to synthesize and essential biological molecule; cannot grow on min medium but can grow on minimal medium to which has been added the biological molecule that it cannot synthesize Term 12 Minimal media Definition 12 Used to culture bacteria or some other microorganism; contains only the nutrients required by prototrophic (wild-type) cells
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12/24/09 1:37 AM Printable Flash Cards Page 5 of 20 http://www.flashcardmachine.com/print/?topic_id=441312 Term 13 complete media Definition 13 Used to culture bacteria or some other microorganism; contains all the nutrients required for growth and synthesis, including those normally synthesized by the organism. Nutritional mutants can grow on complete medium Term 14 Replica Plating Definition 14 when an exact copy of the petri dish containing the colonies is made onto a new petri dish. Cloning Term 15 F+ Definition 15 Donor of plasmid to F- cells. Has region of origin and has genes required to conjugate. Replicates off a single strand of DNA using the rolling circle mode of DNA replication
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12/24/09 1:37 AM Printable Flash Cards Page 6 of 20 http://www.flashcardmachine.com/print/?topic_id=441312 Term 16 F- Definition 16 Do not have plasmids and act as recipient of F plasmid Term 17 High Frequency recombination (Hfr) Definition 17
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This note was uploaded on 12/25/2009 for the course GN 311 taught by Professor Emigh during the Spring '09 term at N.C. State.

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cancer - Printable Flash Cards 12/24/09 1:37 AM Term 1...

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