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Unformatted text preview: -errors in DNA replication-tautomeric shifts - transitions and transversions -replication slippage indel frameshift mutations-spontaneous lesions-depurination-deamination-oxidatively damaged bases 6. Spontaneous mutations in humans-trinucleotide repeat disorders -fragile X syndrome CGG repeats-Huntington and Kennedy diseases CAG repeats 7. The molecular basis of induced mutations-replace a base base analogs 5-BU and 2-AP-alter a base EMS and NG-damage a base UV light and Aflatoxin B 1-intercalating agents proflavin, acridine orange, ICR-191 8. Ames test-reversion test (His-to His + ) in the presence of a compound 9. Cancer mutations in cancer cells-oncogenes example, ras-tumor-suppressor genes example, p53...
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