{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Notes - Chapter 15 - 070307

Notes - Chapter 15 - 070307 - -errors in DNA...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 15 – Mutation 1. Mutations – heritable changes in the DNA sequence - point mutation – alteration of a single base pair or of a small number of adjacent base pairs - chromosomal mutations (chapter 16) – changes in the number or chromosomes or large scale changes in the structure of the chromosome 2. Point mutations - DNA level - base substitution – transition or transversion - deletion or addition - protein level - synonymous mutation - missense mutation - nonsense mutation - frameshift mutation 3. Spontaneous and induced mutations - spontaneous mutations – occurring in all cells at all times - induced mutations – occur in the presence of mutagens that increase the rate at which mutations occur 4. The molecular basis of spontaneous mutations - Luria and Delbruck fluctuation test 5. Mechanisms of spontaneous mutations
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Background image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: -errors in DNA replication-tautomeric shifts - transitions and transversions -replication slippage – indel – frameshift mutations-spontaneous lesions-depurination-deamination-oxidatively damaged bases 6. Spontaneous mutations in humans-trinucleotide repeat disorders -fragile X syndrome – CGG repeats-Huntington and Kennedy diseases – CAG repeats 7. The molecular basis of induced mutations-replace a base – base analogs 5-BU and 2-AP-alter a base – EMS and NG-damage a base – UV light and Aflatoxin B 1-intercalating agents – proflavin, acridine orange, ICR-191 8. Ames test-reversion test (His-to His + ) in the presence of a compound 9. Cancer – mutations in cancer cells-oncogenes – example, ras-tumor-suppressor genes – example, p53...
View Full Document

{[ snackBarMessage ]}

Page1 / 2

Notes - Chapter 15 - 070307 - -errors in DNA...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon bookmark
Ask a homework question - tutors are online