Discussion 10 Fall 2009

Discussion 10 Fall 2009 - caused by this will be (a) AT to...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
GENETICS (BIO 325) Fall 2009 Discussion sheet 10 _____________________________________________________________________________ _ 1. Show the steps (i.e., several replications) by which 5-bromouracil causes the GC base pair shown below to change to an AT base pair. Show the point at which the rare (tautomeric) form of 5-bromouracil gets incorporated in the DNA. Show both products of all divisions in which 5-bromouracil is involved. Do not show chemical structures. 2. Sequential mutations affecting one codon caused the changes arg thr met leu gln What base pair changes produced these amino acid changes? 3. The rare enol form of thymine pairs with guanine. If a thymine enolization occurs during replication, what would be the mutational event? (a) CG to AT (b) GC to TA (c) AT to TA (d) TA to CG (e) CG to GC 4. After mutagen treatment, a molecule of 2-aminopurine (an adenine analogue) incorporates into DNA. During replication the 2-AP protonates. The mutational event
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: caused by this will be (a) AT to CG (b) GC to AT (c) AT to TA (d) AT to GC 1 (e) GC to CG 5. Fragile X syndrome is caused by (a) Extension of trinucleotide repeats (b) 5-Bromouracil (c) Free radicals (d) Depurination (e) Microdeletions 6. During mutagenic treatment with nitrous acid, an adenine deaminates to form hypoxanthine, which behaves like guanine in base-pairing. The mutational event would be (a) AT to CG (b) AT to GC (c) AT to TA (d) GC to AT (e) GC to TA 7. Which of the following mutations will result in cancer? (a) A homozygous recessive mutation in which there is a deletion in the coding region of a proto-oncogene, leaving it non-functional. (b) Homozygous recessive point mutations in a tumor-suppressor gene coding for a non-functional protein. (c) A dominant mutation in a proto-oncogene in which the protein product is overexpressed. (d) A dominant mutation in a tumor-suppressor gene in which the protein product is overexpressed. 2...
View Full Document

This note was uploaded on 12/30/2009 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas at Austin.

Page1 / 2

Discussion 10 Fall 2009 - caused by this will be (a) AT to...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online