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Discussion 10 Fall 2009

Discussion 10 Fall 2009 - caused by this will be(a AT to...

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GENETICS (BIO 325) Fall 2009 Discussion sheet 10 _____________________________________________________________________________ _ 1. Show the steps (i.e., several replications) by which 5-bromouracil causes the GC base pair shown below to change to an AT base pair. Show the point at which the rare (tautomeric) form of 5-bromouracil gets incorporated in the DNA. Show both products of all divisions in which 5-bromouracil is involved. Do not show chemical structures. 2. Sequential mutations affecting one codon caused the changes arg thr met leu gln What base pair changes produced these amino acid changes? 3. The rare enol form of thymine pairs with guanine. If a thymine enolization occurs during replication, what would be the mutational event? (a) CG to AT (b) GC to TA (c) AT to TA (d) TA to CG (e) CG to GC 4. After mutagen treatment, a molecule of 2-aminopurine (an adenine analogue) incorporates into DNA. During replication the 2-AP protonates. The mutational event
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Unformatted text preview: caused by this will be (a) AT to CG (b) GC to AT (c) AT to TA (d) AT to GC 1 (e) GC to CG 5. Fragile X syndrome is caused by (a) Extension of trinucleotide repeats (b) 5-Bromouracil (c) Free radicals (d) Depurination (e) Microdeletions 6. During mutagenic treatment with nitrous acid, an adenine deaminates to form hypoxanthine, which behaves like guanine in base-pairing. The mutational event would be (a) AT to CG (b) AT to GC (c) AT to TA (d) GC to AT (e) GC to TA 7. Which of the following mutations will result in cancer? (a) A homozygous recessive mutation in which there is a deletion in the coding region of a proto-oncogene, leaving it non-functional. (b) Homozygous recessive point mutations in a tumor-suppressor gene coding for a non-functional protein. (c) A dominant mutation in a proto-oncogene in which the protein product is overexpressed. (d) A dominant mutation in a tumor-suppressor gene in which the protein product is overexpressed. 2...
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