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Unformatted text preview: The virus has to be alive in order to make proteins so that Class I can recognize them. P r o Class II MHC pathway Samples proteins outside of the cell. These are phagocytic proteins. There is a invariant chain that acts as a plug in the cleft . UNDERSTAND these pathways are different. Cross presentation by APC to MHCI What if you had an internal Ag but you only have CD8 cells? Somehow some of the degraded proteins in the phagosome got o Each MHC molecule will pick up only a limited subset of peptides HLA is very common. H2K is a mouse molecule. Different peptides can be presented. The stuff in between can be fold out. You also have co-stimulation. Tight signal CD4 with MHC II/ CD8 with MHC I. Virgin B cells can function just like an APC. Th e...
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This note was uploaded on 12/31/2009 for the course MIMG 185 taught by Professor Zack during the Fall '06 term at UCLA.
- Fall '06