Amyloid_assignment

Amyloid_assignment - Uyen Pham PID: A06432690 ESCAPING...

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Uyen Pham PID: A06432690 ESCAPING AMYLOID FATE – News and Views article 1. Escaping amyloid fate” means using small molecules, such as EGCG to prevent amyloid formation (that accompanied diseases such as Alzheimer’s and Parkinson’s) by providing an alternative protein folding pathway. 2. An antagonist means a molecule that without its existence, proteins would resume their normal favorable folding pathway. In this article, EGCG is an antagonist because it opposes/prevents the normal folding pathway that leads to amyloidogenesis. 3. First reason : because of the size of small molecules, it’s hard for them to interfere with protein-protein interaction, which usually happens over a large surface area (much bigger than the molecules’ size). Second reason : the contact area are usually flat thus provides little space for intervention. Besides, the large size proteins can often accommodate small molecules without significant conformational change. 4.
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This note was uploaded on 01/02/2010 for the course BIBC BIBC 100 taught by Professor Buehler during the Fall '09 term at UCSD.

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Amyloid_assignment - Uyen Pham PID: A06432690 ESCAPING...

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