Lecture 1-7

Lecture 1-7 - Mam Fizz 2 (Fall 09) Teaching Assistant Chris...

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Mam Fizz 2 (Fall ’09) Teaching Assistant Chris Childers Table of Contents Lecture 1 / September 25 th , 2009 . ................................................................................................ 2 Lecture 2 / September 28 th , 2009 . ................................................................................................ 3 Lecture 3 / September 30 th , 2009 . ................................................................................................ 5 Lecture 4 / October 2 nd , 2009 . ...................................................................................................... 7 Lecture 5 / October 5 th , 2009. ....................................................................................................... 9 Lecture 6 / October 7 th , 2009. ..................................................................................................... 11 Lecture 7 / October 9 th , 2009. ..................................................................................................... 13
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Lecture 1 / September 25 th , 2009 Introduction & Overview Respiratory Physiology - Anatomy & Histology - Gas Laws: Poiseuille’s, Boyle’s, Dalton’s, Henry’s, LaPlace, Fick’s Ventilation Gas Exchange Gas Transport Regulation Acid/Base Chemistry Exams: Midterm 1: Friday, October 23 rd Midterm 2: Friday, November 20 th Final: Wednesday, December 9 th Sections start 2 nd Week! Suggested Readings: Silverthorn – Chapter 17 West – Chapters 1, 2, 7 Figure 17-1 Overview of external and cellular respiration - Two types of respiration: o External – actual exchange of gases with the outside world (ventilation) o Internal – exchange of gases (CO2, O2) between the alveoli and the blood (diffusion) Includes ventilation/perfusion matching Mismatch problems - Gas transportation: o Gases are rather insoluble in water (example: this is why when you warm up a can of soda it loses its carbonation) o CO2 is 20x more soluble than oxygen at body temperature o This serves as a major challenge for gas transportation and requires additional mechanisms (chemical, hemoglobin etc.) beyond simple dissolution o These chemical reactions will create bicarbonate which acts as the main blood pH buffer o As a result, the regulation of extracellular pH is largely controlled by the respiratory system!! - First exchange – outside environment and the lungs - Second exchange – lungs to the blood - Third exchange – between the blood and the cells o A concentration gradient between the blood, cells and lungs will always be maintained during normal physiological conditions Figure 17-2 Anatomy Summary: The lungs & thoracic cavity - Upper Respiratory Tract: Larynx, Pharynx, Oral Cavity, Nasal Cavity (infected during a common cold) - Lower Respiratory Tract: Trachea, Bronchi, Smaller Bronchi, Bronchioles, Alveoli - Diaphragm – dome shaped muscle which seperates abdoment from the thorax, contraction flattening increasing the volume of the thorax
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This note was uploaded on 01/02/2010 for the course BIPN BIPN 102 taught by Professor Fortes during the Fall '09 term at UCSD.

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Lecture 1-7 - Mam Fizz 2 (Fall 09) Teaching Assistant Chris...

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