Week5 - BIPN 102 Dr. Fortes Lecture 11 10/19 Central &...

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BIPN 102 Chris Childers Dr. Fortes Fall 2009 Lecture 11 – 10/19 Lecture 12 – 10/21 Brain Stem – Medulla and pons Ventilation as a function of PACO2 Ventilation as a function of PAO2 Hiccup reflex (role of phrenic nerve in respiration) Endocrine Regulation Local Regulation Hendersen-Hasselbach Equation (Take I) Lecture 13 – 10/26 Lecture 14 – 10/28 Buffers – proteins, phosphates, ammonia, bicarbonate Hendersen-Hasselbach Equation (Take 2) Proximal Tubule Cell Proximal Tubule Cell Cont. Davenport Plots – metabolic acidosis/alkalosis, respiratory acidosis/alkalosis; response mechanisms 1. Cut below the medulla – No Respiration 2. Cut above the pons – Normal Respiration 3. Cut between the pneumotaxis and apneustic centers – Normal rhythm, long, deep breaths 4. Cut the vagus nerve – Normal rhythm, same duration, but deep breaths 5. Cut the phrenic nerve – Normal rhythm, shallow breaths
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Central Chemoreceptors - Typically account for >70% of ventilation activation - Ventral portion of the medulla, very near the CSF - Chemoreceptors respond to an increase in PCO2 - CO2 diffisues from the capillaries into the CSF and interstitial fluid - CO2 in CSF reacts with water and CA H+ & HCO3- - Central chemoreceptors respond to increase in H+ and also (mildly) to CO2 - Central chemoreceptors respiratory control centers hyperventilation decreased PCO2 (negative feedback loop) Ventilation as a function of alveolar PCO2…. -
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This note was uploaded on 01/02/2010 for the course BIPN BIPN 102 taught by Professor Fortes during the Fall '09 term at UCSD.

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Week5 - BIPN 102 Dr. Fortes Lecture 11 10/19 Central &...

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