BIBC 100 Handout 9

BIBC 100 Handout 9 - BIBC 100 Structural Biochemistry...

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1 BIBC 100 Structural Biochemistry Mimi Nguyen mmnguyen@ucsd.edu Handout 9 (Lecture 23 – 25) OH Fri 10:30–11:30am 1 st Floor S&E Ion Channels Gated-channels o Voltage gated o Ligand gated o Mechanically gated What distinguishes an ion channel from a pore? K + Channel (Bacteria) Lehn Fig. 11.48 and Mol Bio of Cell Fig. 11.23 Structure: 4 identical ___________________ subunits form central pore o Each subunit has 2 TM alpha helices (inner & outer) and a _________ helix o Selectivity loops come together to form _________________ Nicotinic Acetylcholine Receptor Found in post-synaptic neuron and NMJ Ion channel but not for a specific ion; allows ______________ ions Structure: 5 TM subunits (contains 2 ______________________) o Each subunit has 4 alpha helices (M1 – M4) o M2 helix is __________________ and lines the channel with ______________________ residues Mechanism (Lehn Fig. 12.27d) 1) 2) 3) Voltage Gated Na + Channel Voltage-gated channels open and close based on changes in
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This note was uploaded on 01/02/2010 for the course BIBC BIBC 100 taught by Professor Buehler during the Fall '09 term at UCSD.

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BIBC 100 Handout 9 - BIBC 100 Structural Biochemistry...

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