BIBC 100 Handout 10

BIBC 100 Handout 10 - enclosed in an ____________________ 3.

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1 BIBC 100 Structural Biochemistry Mimi Nguyen mmnguyen@ucsd.edu Handout 10 (Lecture 26 – 27) OH Fri 10:30–11:30am 1 st Floor S&E Membrane Fusion Requirements o Recognition o Surfaces must be closely opposed o Local disruption of bilayers o Bilayers fuse Fusion proteins Complementary sets of TM proteins o V-SNARE: ____________, found on surface of synaptic vesicles o T-SNARE: ____________, found on surface of target MB o Trans-SNARE Complex s ___ T-SNARE & ___ V-SNARE helix s ______________ Motif: 7 aa repeat where certain aa are hydrophobic (B&T Fig. 3.2) o Lehn Fig. 11.24 Toxins o Tetanus o Botulinum s Activated by proteolytic cleavage b Heavy chain and Light Chain
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2 Influenza Virus o Basic Structure 1. 2. 3. 4. Infection (Lehn 12.21 3 rd Ed) 1. Virus binds ________________________ on host cell surface 2. ___________________________ is triggered. Virus becomes
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Unformatted text preview: enclosed in an ____________________ 3. __________________________ causes a conformational change in _______________________ 4. MB fusion occurs b Viral __________ released into cytoplasm Hemagglutinin (HA) o Structure (B&T Fig. 5.19) s Single polypeptide _____________________________ into HA1 & HA2 s Functions as ______________ on cell surface s 3 long helices tightly wrapped up (Motif: _______________________) s Receptor binding sites on _____________________________ s At the end of Helix A is ___________ peptide that is rich with ___________________ aa o Two Functions: Viral budding o The presence of sialic acid on the hosts cell plasma MB and viral surface can lead to problems s s Solution? Antigenic Drift vs. Antigenic Shift High pH Low pH...
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BIBC 100 Handout 10 - enclosed in an ____________________ 3.

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