Lecture 8 (Sept 11)

Lecture 8 (Sept 11) - Exam 1 is one week from today Ne xt...

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Exam 1 is one week from today Next Friday, September 18 The test will cover lectures 1-10 (this means through next Wed) Exam Review next wednesday! Here (SC4327), 4-6pm Question-and-Answer Session Only!!! Come prepared with your questions
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Electrochemical gradients and membrane potential Voltage- and ligand-gated ion channels Structure and functional properties of ion channels Ionic basis of the action potential Saltatory conductance in nerve cells Structure and function of the neuromuscular junction The mechanism of synaptic transmission Biological Sciences 110A: Introduction to Biology Kendal Broadie Reading in Chapter 4 (150-170) Karp
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K m 0.6 mM; [Na] ~12 mM (Na+ binds with high affinity) K m 0.2 mM; [K] ~4 mM (K + binds with high affinity) Review : Na+/K+ ATPase establishes electrochemical gradients Fig. 4.45 Karp
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All cells maintain electrical gradients across the plasma membrane A typical cell maintains an electrical potential of ~70 mV (inside negative). Since the plasma membrane is ~3.5 nm thick, this equates to a voltage gradient of 200,000 V/cm! For comparison, high voltage electrical wires have a gradient of 200,000 V per kilometer length. A 100,000-fold difference.
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Differential Distribution of Ions Across the Plasma Membrane ATPase pumps maintain ionic gradients across plasma membrane Electrochemical Gradients (potential energy source) Voltage Recording (potential difference) Voltage-Gated Ion Channels : - Ion selective - Voltage- dependent pore
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Artificial cells with ionic gradients comparable to normal cells without ionic flow there is no potential difference
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This note was uploaded on 01/04/2010 for the course BSCI BSCI 110A taught by Professor Zwiebel during the Spring '09 term at Vanderbilt.

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Lecture 8 (Sept 11) - Exam 1 is one week from today Ne xt...

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