Lecture 9 (Sept 14)

Lecture 9 (Sept 14) - Exam 1 is on Friday, in class The...

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Unformatted text preview: Exam 1 is on Friday, in class The test will cover lectures 1-10 (this means through Wednesday) Exam Review Wednesday! Here (SC4327) at 4pm Question-and-Answer Session Only!!! Come prepared with your questions I will stay as long as questions last only Lecture 9: Types of organelles & biochemical compartments Overview of the endomembrane organelles Membrane and protein trafficking (secretion) Signal Hypothesis: cytosol to ER Membrane translocation & transmembrane proteins Molecular chaperones and protein folding Formation of glycoproteins (glycosylation) The Golgi Complex; trafficking & glycosylation Biological Sciences 110A: Introduction to Biology Kendal Broadie Reading Chapter 8: 274-298 Karp Eukaryotic cells have many membrane-bound organelles Cytosol (many, many processes) Nucleus (DNA genome, transcription and RNA processing) ER (synthesis of secretory and membrane proteins; lipid metabolism) Golgi (processing and sorting of secretory and membrane proteins) Endosomes (processing and sorting incoming materials) Lysosomes (degradation/recycling) Peroxisomes (detoxification) Mitochondria (ATP synthesis) Chloroplasts (photosynthesis) See Fig. 8.1 Karp Relative numbers/volumes of some membrane-bounded organelles in typical mammalian cell How are these membrane compartments maintained? Membrane flows throughout the endomembrane structures continuously and rapidly Membrane is internalized from the plasma membrane through a vesicle budding process called endocytosis . ~2-3% of the membrane internalized per minute! Membranous vesicles fuse with organelles to deliver membrane and vesicle contents. Fusion with the plasma membrane called exocytosis . The entire membrane is recycled in less than 1 hr See Fig. 8.2 Karp Membrane flow during exocytosis and endocytosis is a delicate balance Endocytosis internalizes membrane ~2-3% per minute Exocytosis recycles entire membrane in less than 1 hr Block endocytosis, exocytosis continues: membrane area grows Membrane flow during exocytosis and endocytosis is a delicate balance Block exocytosis, endocytosis continues: membrane area shrinks Endocytosis internalizes membrane ~2-3% per minute Exocytosis recycles entire membrane in less than 1 hr Briefly (minutes) label newly made proteins in secretory cell with radioactive amino acids ( 3 H- leucine,...
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This note was uploaded on 01/04/2010 for the course BSCI BSCI 110A taught by Professor Zwiebel during the Spring '09 term at Vanderbilt.

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Lecture 9 (Sept 14) - Exam 1 is on Friday, in class The...

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