The%20flow%20of%20Genetic%20Mater

The flow of Ge - Wed Chap 13,15(Central Dogma Friday Chap 18 Mutation Wed Cancer Intro Wed Fri Caner Genetics <50 Final> The flow of Genetic

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Wed: Chap 13,15 (Central Dogma), Friday: Chap 18: Mutation, Wed: Cancer Intro, Wed, Fri: Caner Genetics <50% Final> The flow of Genetic Material Transcription: Transfer of genetic material from DNA to RNA The information to make a protein is contained in the bases of DNA contained on one strand (Template strand) This information is transferred to a molecule of RNA by base pairing; mRNA synthesis occurs 5’ 3’ This RNA(messenger RNA or mRNA leaves the nucleus and is translated into proteins in the cytoplasm Different genes may be transcribed from different strands The information to make a protein is contained in the bases of DNA contained on one strand (Template strand) Different genes may be transcribed from different strands Transcription: Transcriptional unit Promoter: Binds protein complex used for transcription and determines start site RNA Coding region DNA region to be transcribed into RNA Terminator region: Sequence of DNA signaling end of transcription Direction of transcription and relative positioning referred to as upstream (of RNA coding region)…transcription proceeds downstream toward terminator regions Transcription: Transcriptional Apparatus RNA Polymerase + accessory proteins: Serves to unwind,polymerize, and rewind DNA Bacterial RNA Polymerase + accessory proteins: Bacterial RNA Polymerase + accessory proteins: Differences between DNA and RNA: Name and structure Sugar Group Nucleotide Bases Base pairings DNA Double Helix Double-stranded Deoxyribose Adenine (A) Guanine(G) Cytosine(C) Thymine(T) A:T C:G RNA Many 2Õ structures Single-stranded (Usual) Ribose Adenine (A) Guanine(G) Cytosine(C) Uracil(U) A:U C:G
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Requires Sigma factor addition to core RNA polymerase allowing binding to promoter and initiating transcription Steps of Transcription: Initiation: RNA polymerase complex binds to Promoter
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This note was uploaded on 01/04/2010 for the course BICD BICD100 taught by Professor Smith during the Fall '09 term at UCSD.

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The flow of Ge - Wed Chap 13,15(Central Dogma Friday Chap 18 Mutation Wed Cancer Intro Wed Fri Caner Genetics <50 Final> The flow of Genetic

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