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ucsdpedigree - The Inheritance of Human Traits Difficulties...

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The Inheritance of Human Traits Difficulties Long generation time Data must be obtained from offspring produced Experimental matings are not possible Limited sample size
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Catalogs of Genetic Traits Figure 4.4
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Fig. 4-2, p.69
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Pedigree Analysis Pedigree is an orderly presentation of family information First step in studying the inheritance of traits Important in predicting genetic risk May be incomplete due to difficulties collecting information
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Examples of Patterns of Inheritance Autosomal Recessive Autosomal Dominant X-Linked Dominant X-Linked Recessive Y-Linked Inheritance Mitochondrial Inheritance
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Pedigree Analysis Construct pedigree using available information Rule out all patterns of inheritance that are inconsistent with the data May not have enough information to identify the mode of inheritance Some genetic disorders may have more than one pattern of inheritance
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Pedigree Symbols
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Pedigree Symbols
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Proband First affected family member who seeks medical attention for a genetic disorder
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Autosomal Recessive Traits For rare traits most affected individuals have unaffected parents Offspring of two affected individuals are affected Expressed in males and females equally In rare traits unaffected parents with affected offspring may be related to each other
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Autosomal recessive
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