ucsdpedigree

ucsdpedigree - The Inheritance of Human Traits Difficulties...

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Unformatted text preview: The Inheritance of Human Traits Difficulties • Long generation time • Data must be obtained from offspring produced • Experimental matings are not possible • Limited sample size Catalogs of Genetic Traits Figure 4.4 Fig. 4-2, p.69 Pedigree Analysis • Pedigree is an orderly presentation of family information • First step in studying the inheritance of traits • Important in predicting genetic risk • May be incomplete due to difficulties collecting information Examples of Patterns of Inheritance • Autosomal Recessive • Autosomal Dominant • X-Linked Dominant • X-Linked Recessive • Y-Linked Inheritance • Mitochondrial Inheritance Pedigree Analysis • Construct pedigree using available information • Rule out all patterns of inheritance that are inconsistent with the data • May not have enough information to identify the mode of inheritance • Some genetic disorders may have more than one pattern of inheritance Pedigree Symbols Pedigree Symbols Proband • First affected family member who seeks medical attention for a genetic disorder Autosomal Recessive Traits • For rare traits most affected individuals have unaffected parents • Offspring of two affected individuals are affected • Expressed in males and females equally • In rare traits unaffected parents with affected offspring may be related to each other Autosomal recessive Cystic Fibrosis Is an Example of an...
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This note was uploaded on 01/04/2010 for the course BICD BICD100 taught by Professor Smith during the Fall '09 term at UCSD.

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ucsdpedigree - The Inheritance of Human Traits Difficulties...

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