BE230_Lecture_4 - Lecture 5 ABC superfamily At end of this...

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Lecture 5 ABC superfamily
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At end of this lecture You will be able to 1. Define ABC superfamily 2. Outline their structure 3. Cite where they are found 4. list examples 5. Describe consequences of defective ABC proteins 6. Explain the ‘flippase’ model of transport by MDR1 and ABCB4
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ATP-binding cassette (ABC) superfamily Several hundred different transport proteins Specific for single substrate or group of related substrates Ions, sugars, amino acids, phospholipids, peptides, polysaccharides, proteins 4 core domains 2 transmembrane domains 2 cytosolic ATP-binding domains
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ABC proteins (superfamily) T domains contain 6 membrane spanning a helices Carry substance across Determine substrate specificity of each ABC protein A domain sequences are 30-40% homologous Common evolutionary origin
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50 ABC pumps in mammals MDR1 First eukaryotic ABC protein Elevated in tumour cells that showed resistance to several drugs Uses energy of ATP hydrolysis to export
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This note was uploaded on 01/05/2010 for the course FSH BT taught by Professor Ianmarison during the Fall '09 term at Dublin City University.

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BE230_Lecture_4 - Lecture 5 ABC superfamily At end of this...

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