Wingfield 1

The cyclical peptides differ in only 2 amino acid

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Unformatted text preview: The Posterior Pituitary (neurophysis, pars nervosa) hormones. Arginine Vasopressin (AVP) a.k.a. vasopressin, anti-diuretic hormone. Oxytocin Some effects of vasopressin Neuroendocrine posterior pituitary: water retention in kidney tubules; smooth muscle contraction in blood vessels; Neuroendocrine anterior pituitary: regulation of adrenocorticotropin-releasing hormone. Central (within the brain): learning and memory, aggression. Some effects of oxytocin Neuroendocrine posterior pituitary: Smooth muscle contraction in uterus, milk-let-down reflex. Neuroendocrine anterior pituitary: regulation of adrenocorticotropin-releasing hormone. Central (within the brain): learning and memory, pairbonding, social affiliation. Paraventricular
 nucleus
 Neurosecretory
 neurons
 =
Vasopressin
 =
Oxytocin
 Hypothalamus
 SupraopBc
 nucleus
 Hypothalamic–posterior
 pituitary
stalk
 Anterior
 pituitary
 Posterior
pituitary
 Systemic
 arterial
inflow
 Systemic
 venous
ouflow
 Fig.
18‐6
(1),
p.
663
 The structural and chemical characteristics of Vasopressin and Oxytocin. The cyclical peptides differ in only 2 amino acid positions. Both contain disulphide bridges between cysteine residues at positions 1 and 6. ARGININE VASOPRESSIN PRE-PRO-PEPTIDE 5' 1-19 93 96 39 Glyco- 3' Signal
 Peptide pepBde
 AVP Signal Neurophysin II Neurophysin
II
 peptide Glyco‐
 protein
 OXYTOCIN PRE-PRO-PEPTIDE 5' 1-19 93 96 NEUROPHYSIN I Neurophysin
I
 3' Signal
 Peptide pepBde
OXYTOCIN 



Oxytocin




 Structural organization of the Vasopressin-neurophysin II gene. The VPNPII gene has 3 exons. The larger preprohormone precursor undergoes substantial post-translational modification. The OT gene has a similar structure, and undergoes similar processing and post-translational modification. AVP: Vasopressin; NPII : Neurophysin II. Signal 
 
 
 
 
 
Vasopressin
receptor
subtypes
 
 
 
 
 
V1 



















 
 
V2 




















 
 
V3
 Expression
 




 
Vascular
smooth


 
Basolateral
membrane
 





Pituitary
 
 
 

muscle,
liver,
 






of
distal
nephron
 
 



corBcotrope
 
 
 
Platelets,
CNS




 

 
 

 






Amino
acid
structure
418





370
amino
acid













424
amino
acids
 





amino
acids
 
 
 

 Second
messenger
system 

 
 
Gq/11mediated
 





 
Ga
s
mediated
adenylate









As...
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This note was uploaded on 01/06/2010 for the course NPB idk taught by Professor Wingfield during the Spring '09 term at UC Davis.

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