Wingfield 1

Wingfield 1

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Unformatted text preview: NPB
101,
Autumn
2008
 Endocrinology
1
 What
do
hormones
do?
 Hypothalamo‐pituitary
unit
 Posterior
pituitary
 Sensory
modaliBes
 for
external
cues
 Auditory
 Visual
 Chemical
(taste/smell)
 TacBle
 Baroreceptor
 Types
of
internal
 cues
 Blood
glucose,
amino
acids,
 free
faKy
acids,
vitamins,
 minerals
etc.
 Salt
and
water
balance
 InfecBon
and
other
diseases
 Endogenous
rhythms
‐

 biological
clock
 FuncBon
of
NeurotransmiKers,

Hormones,
etc.
 NeurotransmiKers
propagate
or
terminate
electrical
signals,
 influence
muscle
contracBon
at
neuromuscular
juncBons,
 affect
hormone
release,
or
other
secreBons
such
as
enzymes,
 regulate
ion
and
other
channels
etc.
 Hormones
affect
synthesis
and
release
of
other
hormones
 Influence
metabolism
 SBmulate
muscle
contracBon
 Regulate
reproducBon
 Integrate
growth
 Control
osmoregulaBon

 Permissive
acBons
 Behavioral
effects
 FacultaBve
acBons
 Hormone
type
–
what
does
it
do?
 Mechanism
of
control
(of
synthesis
and
secreBon)
 Mechanism
of
acBon
(receptors
etc.)
 Fig.
5‐13,
p.
149
 An
oversimplified

 linkage
sequence

 among
funcBonal
 areas
of
the
cortex
 in
relaBon
to
input
 and
output.
 Hypothalamus
and
 neuroendocrine
 secreBons
 Environmental
cues
 ?
 ?
 Hypothalamus
 Adenohypophysis
 Tropic
effects
on
peripheral
 endocrine
Bssues,
e.g.
on
 thyroid,
adrenals,
gonads
 and
liver
 Neurohypophysis
 Brain
 ?
 ?
 Brain
pepBdes
 central
acBons
 Effects
on
largely
non‐
 Effects
on
smooth
muscle
 endocrine
Bssues,
e.g.
 contracBon
(vascular

 skeleton,
muscles,
adipose
 system,
genital
tract),

 Bssue,
integument
and
liver

water
balance,
kidney
 Endocrine
Bssues
that
are
not
principle
targets
 of
the
hypothalamo‐pituitary
unit
 Parathyroid
and
ulBmobranchial
cells
that
regulate
calcium
levels

 in
cells
and
blood.
 Gastro‐intesBnal
tract
cells
that
orchestrate
digesBon.
 PancreaBc
endocrine
cells
that
control
blood
sugar
levels
as
well

 as
amino
acid
and
faKy
acid
uptake.
 Liver
cells
that
release
vitamin
D
(calcium
uptake
from
gut)
or

 pre‐hormones.
 Kidney
cells
that
release
an
enzyme
renin
involved
in
acBvaBng
 hormones
that
regulate
sodium
retenBon.
 Adrenal
chro...
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This note was uploaded on 01/06/2010 for the course NPB idk taught by Professor Wingfield during the Spring '09 term at UC Davis.

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