Lec 3 A Case for Evolutionary Thinking-9-2

Lec 3 A Case for Evolutionary Thinking-9-2 - A Case for...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
A Case for Evolutionary Thinking: Understanding HIV Sep 2 nd , 2009 Reading: Freeman & Herron Chapter 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Evolution: How to adapt to changing environments? How to form new species? 1. Evolution of Drug resistance of HIV 2. Evolution of human resistance to HIV infection 3. Origin of HIV---Power of phylogenetic tree reconstruction
Background image of page 2
Human immunodeficiency virus (HIV) 101 1.RNA virus: viruses possessing an RNA genome 2. Replicate via a DNA intermediate. Use the enzyme reverse transcriptase to perform the reverse transcription of its genome from RNA into DNA 3. Integrate into the host's genome with an integrase enzyme. The virus then replicates as part of the cell's DNA.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
gag (coding for the viral capsid proteins) pol (coding for reverse transcriptase) env (coding for HIV's envelope-associated proteins) The regulatory genes: tat, rev, nef, vif, vpr, vpu (not present in HIV-2) vpx (not present in HIV-1) Human immunodeficiency virus (HIV) 101
Background image of page 4
HIV-2 is transmitted in the same ways as HIV-1. Both HIV-1 and HIV-2 can develop into AIDS Immunodeficiency develops more slowly and is milder in persons with HIV-2. People infected with HIV-2 are less infectious in the early stages of the virus than those with HIV-1. The infectiousness of HIV-2 increases as the virus progresses. Most reported cases of HIV-2 are found in West Africa. There are few reported cases of HIV-2 in the United States. Human immunodeficiency virus (HIV) 101
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 31

Lec 3 A Case for Evolutionary Thinking-9-2 - A Case for...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online