Week 4 Handout Final

Week 4 Handout Final - Jonathan Goldstone BIBC 100 Week 4...

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Jonathan Goldstone BIBC 100 - Week 4 [email protected] LECTURE 7 Finishing up Immunoglobulins: Mechanism of MHC: -There are invariant regions that bind to the N and C terminus -However, there are also several variable specificity pockets that provide the extra binding energy -Specific characteristics for high affinity binding -Therefore the Ag binding site does not have to be specific, except  for the variable specificity pockets, so a given MHC with certain specificity pockets can bind to any given peptide that matches these specific interactions, and it will bind very tightly Summary -Class I MHC molecules binds to peptides that are 8-10 aa long -N and C termini form H-bonds with conserved MHC residues -Variable specificity pockets allow for high affinity binding Class II MHC: -Slight changes in detail -Structure is slightly different, don’t worry about it -Can bind to a larger peptide, which can hang out of the ends Imunoglobulins: -Constant domain of IgG has immunoglobulin fold motif (MHC α 1 and ß2m have this as well) -Tcell Receptor: also has immunoglobulin fold in constant regions and
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This note was uploaded on 01/07/2010 for the course BIBC BIBC 100 taught by Professor Buehler during the Spring '09 term at UCSD.

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Week 4 Handout Final - Jonathan Goldstone BIBC 100 Week 4...

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