Week 4 Handout Final

Week 4 Handout Final - Jonathan Goldstone BIBC 100 Week 4...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Jonathan Goldstone BIBC 100 - Week 4 [email protected] LECTURE 7 Finishing up Immunoglobulins: Mechanism of MHC: -There are invariant regions that bind to the N and C terminus -However, there are also several variable specificity pockets that provide the extra binding energy -Specific characteristics for high affinity binding -Therefore the Ag binding site does not have to be specific, except  for the variable specificity pockets, so a given MHC with certain specificity pockets can bind to any given peptide that matches these specific interactions, and it will bind very tightly Summary -Class I MHC molecules binds to peptides that are 8-10 aa long -N and C termini form H-bonds with conserved MHC residues -Variable specificity pockets allow for high affinity binding Class II MHC: -Slight changes in detail -Structure is slightly different, don’t worry about it -Can bind to a larger peptide, which can hang out of the ends Imunoglobulins: -Constant domain of IgG has immunoglobulin fold motif (MHC α
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern