Week 5 Handout

Week 5 Handout - BIBC 100 Week 5 Jonathan Goldstone...

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BIBC 100 – Week 5 5/1/09 Jonathan Goldstone jongoldstone@ucsd.edu Myocin Structure is 6 subunits (2 Heavy, 4 Light) ATP hydrolyzing Domain @ N-terminal end 1. Myocin bound tight to actin (rigor conformation) 2. ATP binds to myocin Leads to conformational change in actin binding site Reduces the affinity of myocin for actin Bound actin is released 3. ATP is hydrolyzed Leads to conformational change (high energy state) 4. Myocin binds weakly at new site on actin & this releases the ADP + Pi which now causes tight binding of myocin to actin. This triggers a quick return to the resting state; ADP is released. Enzymes Bind to one or more ligands called substrates, converting them into products Enzymes themselves are not changed in reaction, which is carried out in the active site E + S <-> ES <-> EP <-> E + P Enormous catalytic power – enzymes greatly speed up reactions by LOWERING ACTIVATION ENERGY (and they speed up the reaction a lot)
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Week 5 Handout - BIBC 100 Week 5 Jonathan Goldstone...

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