Week 6 Handout

Week 6 Handout - Jonathan Goldstone BIBC 100 - Week 6...

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Jonathan Goldstone BIBC 100 - Week 6 [email protected] Enzyme Regulation: 1. Allosteric control - 2. Reversible covalent modification – Phosphorylation/Ubiquitination 3. Proteolytic activation (cleavage) – Chymotrypsinogen chymotrypsin via Trypsin activity etc… INFLUENZA Virus (virion) o DNA or RNA genetic code o Contained in protein coat (capsid) or enveloped by lipid membrane o Surface proteins very important for infection Influenza o Enveloped RNA virus o Main surface proteins – Hemagglutinin  (HA) and Neuraminidase   (NM) o Mechanism of entry into cell HA binds to sialic acid on host cell surface Triggers endocytosis; becomes enclosed in an endosome Endosome is acidified due to proton pumps on membrane Acidification leads fusion of the viral and the endosomal membrane Viral genome relocated into cytoplasm o Hemagglutinin (HA) HA mediates binding of viral particles to host cell via sialic acid binding Synthesized as a single polypeptide Proteolytically
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This note was uploaded on 01/07/2010 for the course BIBC BIBC 100 taught by Professor Buehler during the Spring '09 term at UCSD.

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Week 6 Handout - Jonathan Goldstone BIBC 100 - Week 6...

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