Week 7 Handout

Week 7 Handout - BIBC 100 Jonathan Goldstone Week 7...

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BIBC 100 Jonathan Goldstone jgoldstone@ucsd.edu Week 7 Membranes 1. Protection 2. Isolate Functions 3. Signal Transduction 4. Highly Selective Permeable Barriers 5. Fusion 6. Energy Conversion a. Photosynthesis b. Oxidative Phospohrylation Membrane Composition o Mostly lipids and proteins, bilayer is ~50-80 Å thick, non-covalent interactions o Lipid is amphipathic with polar hydrophilic head group and hydrophobic tail o Depending on conditions and type of lipid, forms different structures Micelles – individual units are wedge-shaped Bilayer – Self-assembling, driven by hydrophobic interactions Vesicle – a bilayer sheet is energetically unfavourable at the edges, so it will spontaneously curve into a vesicle to minimize this Types of lipids o Phospholipids Glycerophospholipids Glycerol + 2 FA tails + P head group One tail is saturated, other is NOT, so it has a kink! Fig 10-7 don’t have to memorize, just recognize the names Sphingomyelin (a particular sphingolipid) Polar head group with two nonpolar tails Made from Sphingosine, a long chain alcohol, instead of glycerol PE, PC*, SM, PS (only negatively charged)
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This note was uploaded on 01/07/2010 for the course BIBC BIBC 100 taught by Professor Buehler during the Spring '09 term at UCSD.

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Week 7 Handout - BIBC 100 Jonathan Goldstone Week 7...

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