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Unformatted text preview: FATTY ACID OXIDATION (TUNE:“THERE IS A TAVERN IN THE TOWN”) O bje c t 1 There is a Tavern in the Town Midi There is a Tavern in the Town MP3 There is a pathway in the cell (in the cell) That metabolizes well (awfully well) Fatty acyl chains in a most effective way To acetyl coenzyme A. It’s called b oxidation, and by way of explanation In the mitochondrial matrix is the major part. It starts however on the cytosolic side With fatty acids coming from triglyceride Activated in the thiokinase way To thioester of CoA Acyl CoA can’t permeate (permeate) The inner membrane to its fate (sad to state) But a transferase now comes upon the scene Making fatty acyl carnitine. And there now is permeation, and a new transacylation Generating acyl CoA in the matrix space. We now begin upon an oxidation phase With FAD-dependent dehydrogenase (The flavoprotein is oxidized again to UQ, thence by the chain)....
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- Spring '09
- Fatty acid metabolism, acyl CoA, CoA acyl CoA