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65 - 1 Can J Gastroenterol 1999 Nov;13(9:753-9 Peptic ulcer...

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Sheet1 Page 1 1. Can J Gastroenterol. 1999 Nov Peptic ulcer at the end of the 20th century: biological and psychological risk factors. Levenstein S. Gastroenterology Division, San Camillo-Forlanini Hospital, Rome, Italy. [email protected] The prevailing concept of peptic ulcer etiology has swung over entirely in just a few years from the psychological to the infectious, yet the rich literature documenting an association between psychosocial factors and ulcer is not invalidated by the discovery of Helicobacter pylori. Physical and psychological stressors interact to induce ulcers in animal models, concrete life difficulties and subjective distress predict the development of ulcers in prospective cohorts, shared catastrophes such as war and earthquakes lead to surges in hospitalizations for complicated ulcers, and stress or anxiety can worsen ulcer course. Many known ulcer risk factors, including smoking, nonsteroidal anti-inflammatory drug use, heavy drinking, loss of sleep and skipping breakfast,
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