67 - 1 N Engl J Med 1996 May 30;334(22:1435-9 Famotidine...

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Sheet1 Page 1 1. N Engl J Med. 1996 May 30 334(22):1435-9. Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. Taha AS, Hudson N, Hawkey CJ, Swannell AJ, Trye PN, Cottrell J, Mann SG, Simon TJ, Sturrock RD, Russell RI. Department of Gastroenterology, Glasgow Royal Infirmary, Scotland. Comment in: ACP J Club. 1996 Nov-Dec 125(3):79. N Engl J Med. 1996 Oct 24 335(17):1322 BACKGROUND. Acid suppression with famotidine, a histamine H2-receptor antagonist, provides protection against gastric injury in normal subjects receiving short courses of aspirin or naproxen. The efficacy of famotidine in preventing peptic ulcers in patients receiving long-term therapy with nonsteroidal antiinflammatory drugs (NSAIDs) is not known. METHODS. We studied the efficacy of two doses of famotidine (20 mg and 40 mg, each given orally twice daily), as compared with placebo, in preventing peptic ulcers in 285 patients without peptic ulcers who were receiving long-term NSAID therapy for rheumatoid arthritis (82 percent) or osteoarthritis (18 percent). The patients were evaluated clinically and by
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