Sheet1 Page 1 1. J Epidemiol Community Health. 1992 Aug 46(4):428-32. Channelling of controlled release formulation of ketoprofen (Oscorel) in patients with history of gastrointestinal problems. Leufkens HG, Urquhart J, Stricker BH, Bakker A, Petri H. Department of Pharmaco-epidemiology, Utrecht University, The Netherlands. STUDY OBJECTIVE--The aim was to determine if a new controlled release formulation (Oscorel) of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen has been preferentially prescribed in patients with prior history of gastro-intestinal disturbances. DESIGN--The study was a pharmacy records based comparison of the rates of prior prescribing of drugs indicated for peptic ulcer treatment in first recipients of Oscorel in 1989 versus recipients of other NSAID products. SETTING--A representative panel of Dutch community pharmacies serving approximately 425,000 people was used. MAIN RESULTS--Oscorel was launched in January 1989. Data on prescriptions dispensed in 1987-1988 to a total of 837
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