76 - complication (odds ratio 1.1 rates of prior use of...

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Sheet1 Page 1 1. Br Med J (Clin Res Ed). 1987 Nov 14 Fatal peptic ulcer complications and the use of non-steroidal anti-inflammatory drugs, aspirin, and corticosteroids. Henry DA, Johnston A, Dobson A, Duggan J. Discipline of Clinical Pharmacology, University of Newcastle, Royal Newcastle Hospital, Australia. Although non-steroidal anti-inflammatory drugs are known to cause peptic ulcer and its complications, controversy exists about the number of deaths from ulcer which are attributable to their use. A case-control study was therefore performed to determine whether prior use of non-steroidal and other anti-inflammatory compounds was associated with an increased case fatality rate from complications of peptic ulcer. Non-steroidal anti-inflammatory drugs were used by 39% of a series of 80 patients who had died from peptic ulcer complications and by 37% of 160 controls who were survivors matched for sex, age, ulcer site, and nature of
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Unformatted text preview: complication (odds ratio 1.1 rates of prior use of aspirin by cases and controls were almost identical (odds ratio 1.2 anti-inflammatory drugs nor aspirin were associated with increased case fatality rates from peptic ulcer complications. In contrast, corticosteroids were associated with an increased mortality (odds ratio 4.2 0.9 to 25.6). Although this increase in the estimated relative risk was not statistically significant, a review of the case records indicated that most deaths in steroid users were due to serious sepsis, indicating that there might be a causal association between use of the drugs and the mode of death. PMCID: PMC1248302 PMID: 3120956 [PubMed - indexed for MEDLINE] Sheet1 Page 2 295(6608):1227-9. 95% confidence interval 0.6 to 2.1). Similarly, the 95% confidence interval 0.5 to 1.9). Thus neither nonsteroidal 95% confidence interval...
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This note was uploaded on 01/10/2010 for the course NSA 1010 taught by Professor Ahobaishi during the Spring '09 term at ND State.

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76 - complication (odds ratio 1.1 rates of prior use of...

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