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30 - 1 Aliment Pharmacol Ther 2007 Apr 15;25(8:907-12...

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Sheet1 Page 1 1. Aliment Pharmacol Ther. 2007 Apr 15 Introduction of newer selective cyclo-oxygenase-2 inhibitors and rates of hospitalization with bleeding and perforated peptic ulcer. Christensen S, Riis A, Nørgaard M, Thomsen RW, Sørensen HT. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. [email protected] BACKGROUND: Limited data exist on the impact of the introduction of newer selective cyclo-oxygenase-2 inhibitors into clinical practice in 1999 on overall non-steroidal anti-inflammatory drug use and hospitalization rates of complicated peptic ulcer disease at the population level. AIM: To examine these issues, we conducted a population-based study in western Denmark, within a population of 1.2 million. METHODS: All patients with perforated (n = 1488) or bleeding peptic ulcer (n = 6017) between 1996 and 2004 were identified in hospital discharge registries. We computed standardized annual hospitalization rates and hospitalization rate ratios using Poisson regression. Data on annual number of
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