28 - 1. BMC Musculoskelet Disord. 2007 Aug 3;8:73....

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Sheet1 Page 1 1. BMC Musculoskelet Disord. 2007 Aug 3 Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: balancing gastrointestinal and cardiovascular risk. Moore RA, Derry S, McQuay HJ. Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford, UK. andrew.moore@pru.ox.ac.uk BACKGROUND: Differences between gastrointestinal and cardiovascular effects of traditional NSAID or cyclooxygenase-2 selective inhibitor (coxib) are affected by drug, dose, duration, outcome definition, and patient gastrointestinal and cardiovascular risk factors. We calculated the absolute risk for each effect. METHODS: We sought studies with large amounts of information to calculate annualised rates for clearly defined gastrointestinal (complicated upper gastrointestinal perforations, ulcers, or bleeds, but not symptomatic or endoscopic ulcers) and serious cardiovascular outcomes (antiplatelet trial collaborators - APTC - outcome of fatal or nonfatal myocardial infarction or
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28 - 1. BMC Musculoskelet Disord. 2007 Aug 3;8:73....

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