19 - 1. Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:44-9....

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Sheet1 Page 1 1. Aliment Pharmacol Ther. 2000 Apr The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts. Takahashi M, Katayama Y, Takada H, Kuwayama H, Terano A. Department of Gastroenterology and Hepatology, University Hospital at Koshigaya, Dokkyo University School of Medicine, Saitama, Japan. mtak@dokkyomed.ac.jp BACKGROUND: There is compelling evidence for the pivotal role of Helicobacter pylori in the pathogenesis of gastrointestinal ulcer disease. However, despite the bacterium's toxicity, the majority of H. pylori infections are not accompanied by gastric ulcers. This implies the existence of a host mechanism offsetting H. pylori toxicity. AIMS: To evaluate gastric fibroblasts' expression of hepatocyte growth factor (HGF), which is known to facilitate gastric ulcer healing, in the presence of H. pylori HGF expression of a COX-2 selective inhibitor with that of nonselective nonsteroidal anti-inflammatory drugs METHODS: Human gastric fibroblasts were
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19 - 1. Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:44-9....

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