15 - by NSAIDs. However, the mechanism by which this occurs...

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Sheet1 Page 1 1. Mol Pharmacol. 2005 Oct Geranylgeranylacetone protects membranes against nonsteroidal anti-inflammatory drugs. Ushijima H, Tanaka K, Takeda M, Katsu T, Mima S, Mizushima T. Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan. Direct gastric mucosal cell damage mediated by nonsteroidal anti-inflammatory drugs (NSAIDs) is involved in the formation of NSAID-induced gastric lesions. We recently suggested that this direct cytotoxicity of NSAIDs is caused by their membrane-permeabilization activity. Geranylgeranylacetone (GGA), a clinically used antiulcer drug, can protect gastric mucosa against lesion formation mediated
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Unformatted text preview: by NSAIDs. However, the mechanism by which this occurs is not fully understood. In this study, we show that GGA acts to stabilize membranes against NSAIDs. GGA suppressed NSAID-induced permeabilization of calcein-loaded liposomes and NSAID-induced stimulation of K(+)-efflux across the cytoplasmic membrane in cells. GGA was effective even when coadministered with NSAIDs and was also able to restore membrane fluidity that had been compromised by NSAIDs. This mechanism seems to play an important role in the antiulcer activity of GGA. PMID: 16046660 [PubMed - indexed for MEDLINE] Sheet1 Page 2 68(4):1156-61. Epub 2005 Jul 26....
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This note was uploaded on 01/10/2010 for the course NSA 1010 taught by Professor Ahobaishi during the Spring '09 term at ND State.

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15 - by NSAIDs. However, the mechanism by which this occurs...

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