13 - 1. Arq Gastroenterol. 2006 Jul-Sep;43(3):233-7. The...

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Sheet1 Page 1 1. Arq Gastroenterol. 2006 Jul-Sep The cytoprotective effect of a nitric oxide donor drug on gastric mucous membrane of rats treated with ketoprofen, a non-steroidal anti-inflammatory drug. Villa AL, Reginaldo C, Viaro F, Ramalho F, Campos AD, Evora PR. Divisão de Cirurgia Experimental, Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeiro Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. BACKGROUND: Non-steroidal anti-inflammatory drugs are considered today a very important group of medication, with a wide variety of therapeutic use, in different areas of modern medicine. Despite their beneficial effects on the patient, these drugs show a high incidence of side effects, mainly in the gastrointestinal tract. The physiopathological mechanisms of non-steroidal anti-inflammatory drugs induced lesions and the gastric mucosa defense mechanism became an important source for medical research, especially those which try to evaluate the role of nitric oxide as a cytoprotective agent. AIM: To define a
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This note was uploaded on 01/10/2010 for the course NSA 1010 taught by Professor Ahobaishi during the Spring '09 term at ND State.

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13 - 1. Arq Gastroenterol. 2006 Jul-Sep;43(3):233-7. The...

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