12 - Furthermore, they exert gastroprotective actions in...

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Sheet1 Page 1 1. J Pharmacol Sci. 2007 Jul Gastroprotective role of glucocorticoid hormones. Filaretova L, Podvigina T, Bagaeva T, Bobryshev P, Takeuchi K. Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Makarova 6, St. Petersburg, 199034, Russia. filaretova@pavlov.infran.ru Gastric ulcer disease remains widespread antiinflammatory drugs (NSAIDs) make significant contributions to this pathological situation. The findings overviewed here support the idea that glucocorticoid hormones released in response to acute stress or NSAIDs act as gastroprotective substances and exert many of the same actions in the stomach as prostaglandins (PGs) and nitric oxide (NO) as well as capsaicin-sensitive afferent neurons. Glucocorticoids exert a gastroprotective effect by both maintaining local defensive factors (mucosal blood flow and mucus production) and inhibiting pathogenic elements (gastric motility and microvascular permeability).
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Unformatted text preview: Furthermore, they exert gastroprotective actions in co-operation with PGs, NO, and the afferent neurons protective mechanism provided by either of these factors is impaired. The gastroprotective action of glucocorticoids is also associated with maintenance of general body homeostasis, including blood glucose levels and systemic blood pressure. In conclusion, glucocorticoids released in response to acute stress or NSAIDs are naturally occurring protective factors that play an important role in maintenance of the gastric mucosal integrity. This led us to re-evaluate the traditional paradigm that glucocorticoid hormones produced during activation of the hypothalamic-pituitary-adrenocortical axis are ulcerogenic in the stomach. PMID: 17598953 [PubMed - indexed for MEDLINE] Sheet1 Page 2 104(3):195-201. Epub 2007 Jun 29. a stressful lifestyle and nonsteroidal and their compensatory action is observed when the...
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12 - Furthermore, they exert gastroprotective actions in...

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