8 - 1 Br J Pharmacol 2007 Apr;150(7:913-9 Epub 2007 Feb 26...

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Sheet1 Page 1 1. Br J Pharmacol. 2007 Apr Surface phospholipids in gastric injury and protection when a selective cyclooxygenase-2 inhibitor (Coxib) is used in combination with aspirin. Lichtenberger LM, Romero JJ, Dial EJ. The Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, TX 77030, USA. [email protected] BACKGROUND AND PURPOSE: Clinical studies demonstrate that aspirin consumption reverses the gastrointestinal (GI) benefits of coxibs, by an undefined mechanism. EXPERIMENTAL APPROACH: Rodent models were employed to investigate the effects of combinations of celecoxib and aspirin on gastric ulcerogenesis, bleeding, surface hydrophobicity (by contact angle analysis) and ulcer healing. We also evaluated the effects of phosphatidylcholine (PC)-associated aspirin in these rodent models and confirmed its cyclooxygenase (COX)-inhibitory activity by measuring mucosal prostaglandin E(2) (PGE(2)) concentration. We present evidence that aspirin's
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This note was uploaded on 01/10/2010 for the course NSA 1010 taught by Professor Ahobaishi during the Spring '09 term at ND State.

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8 - 1 Br J Pharmacol 2007 Apr;150(7:913-9 Epub 2007 Feb 26...

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