Sheet1Page 11. Gut. 2003 Apr52(4):490-5.Aspirin inhibits the growth of Helicobacter pylori and enhances itssusceptibility to antimicrobial agents.Wang WH, Wong WM, Dailidiene D, Berg DE, Gu Q, Lai KC, Lam SK, Wong BC.Department of Gastroenterology, First Hospital, Peking University, Beijing,China. [email protected]BACKGROUND AND AIM: The role of Helicobacter pylori and aspirin in peptic ulcerformation and recurrence remains an important clinical topic. The interactionbetween aspirin and H pylori in vitro is also not clear. We investigated theeffect of aspirin on the growth of H pylori and on the susceptibility of H pylorito antimicrobials. METHODS: Time killing studies of H pylori were performed with different concentrations of aspirin and salicylate. Growth of bacteria wasassessed spectrophotometrically and by viable colony count. The effects ofaspirin on the efficiency of colony formation and on metronidazole inducedmutation to rifampicin resistance in H pylori were determined. Minimal inhibitoryconcentrations (MICs) of aspirin and metronidazole were tested by the standard
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