4 - 1. Gut. 2003 Apr;52(4):490-5. Aspirin inhibits the...

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Sheet1 Page 1 1. Gut. 2003 Apr 52(4):490-5. Aspirin inhibits the growth of Helicobacter pylori and enhances its susceptibility to antimicrobial agents. Wang WH, Wong WM, Dailidiene D, Berg DE, Gu Q, Lai KC, Lam SK, Wong BC. Department of Gastroenterology, First Hospital, Peking University, Beijing, China. bcywong@hku.hk BACKGROUND AND AIM: The role of Helicobacter pylori and aspirin in peptic ulcer formation and recurrence remains an important clinical topic. The interaction between aspirin and H pylori in vitro is also not clear. We investigated the effect of aspirin on the growth of H pylori and on the susceptibility of H pylori to antimicrobials. METHODS: Time killing studies of H pylori were performed with different concentrations of aspirin and salicylate. Growth of bacteria was assessed spectrophotometrically and by viable colony count. The effects of aspirin on the efficiency of colony formation and on metronidazole induced mutation to rifampicin resistance in H pylori were determined. Minimal inhibitory
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This note was uploaded on 01/10/2010 for the course NSA 1010 taught by Professor Ahobaishi during the Spring '09 term at ND State.

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