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Unformatted text preview: cytoprotective effect of NC-1300-O-3 was not affected by pretreatment with indomethacin but was partly decreased by N-ethylmaleimide pretreatment, suggesting the participation of endogenous sulfhydryl compounds in the action of NC-1300-O-3. This compound dose-dependently increased the hexosamine content in the gastric lumen in rats at a dose range of 3-30 mg/kg, p.o. and slightly inhibited a reduction in surface mucus and mucosal hexosamine content caused by necrotizing agents. Moreover, NC-1300-O-3 at doses of 10 and 30 mg/kg, p.o. significantly inhibited the increased gastric vascular permeability caused by alcohol treatment difference caused by aspirin in rats. These actions were suggested to contribute to the cytoprotective effect of NC-1300-O-3. PMID: 8089937 [PubMed - indexed for MEDLINE] Sheet1 Page 2 65(1):9-18. and at 30 mg/kg, p.o., it inhibited the reduction in potential...
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- Spring '09
- Mucus, necrotizing, cytoprotective effect