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3 - cytoprotective effect of NC-1300-O-3 was not affected...

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Sheet1 Page 1 1. Jpn J Pharmacol. 1994 May Cytoprotective effect of NC-1300-O-3 against gastric lesions induced by necrotizing agents in rats. Matsukura H, Masuda M, Kawaguchi K, Uchida A, Kamishiro T. Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama, Japan. The cytoprotective effect of NC-1300-O-3 and its mechanism of action were investigated. NC-1300-O-3 at doses of 3 and 10 mg/kg, p.o. significantly prevented the formation of gastric lesions by HCl.ethanol in rats, and its efficacy was not influenced by repeated administration for up to 4 weeks. The interaction between NC-1300-O-3 and necrotizing agents in the stomach, which is considered to be related to the development of cytoprotection, was not observed. A preventive effect of NC-1300-O-3 against gastric lesions was observed at the same dose even when gastric secretion was completely inhibited by pretreatment with omeprazole. This suggests that the cytoprotective effect of NC-1300-O-3 is an action on the gastric mucosa independent of its antisecretory effect. The
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Unformatted text preview: cytoprotective effect of NC-1300-O-3 was not affected by pretreatment with indomethacin but was partly decreased by N-ethylmaleimide pretreatment, suggesting the participation of endogenous sulfhydryl compounds in the action of NC-1300-O-3. This compound dose-dependently increased the hexosamine content in the gastric lumen in rats at a dose range of 3-30 mg/kg, p.o. and slightly inhibited a reduction in surface mucus and mucosal hexosamine content caused by necrotizing agents. Moreover, NC-1300-O-3 at doses of 10 and 30 mg/kg, p.o. significantly inhibited the increased gastric vascular permeability caused by alcohol treatment difference caused by aspirin in rats. These actions were suggested to contribute to the cytoprotective effect of NC-1300-O-3. PMID: 8089937 [PubMed - indexed for MEDLINE] Sheet1 Page 2 65(1):9-18. and at 30 mg/kg, p.o., it inhibited the reduction in potential...
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