PGY300lec2GI

PGY300lec2GI - Regulation of Gastrointestinal Functions Dr...

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Regulation of Gastrointestinal Functions Dr John A. Krasney Silverthorn pages 682-684,690-698
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Gastrointestinal Motility Regulated by Enteric Nervous System and GI peptides: Submucosal Plexus Myenteric Plexus Single unit smooth muscle Pacemakers (interstitial cells of Cajal) Gap Junctions Ca ++ is involved in slow wave potentials and action potentials. Basal Electrical Rhythm (B.E.R)
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B.E.R
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Excitation-contraction Coupling Ca ++ entry during action potential initiates smooth muscle contraction. Parasympathetics (acetylcholine) stimulate. Sympathetics (norepinephrine) inhibit. GI hormones (gastrin, cholecystokinin) and paracrines (nitric oxide, histamine) can inhibit or stimulate motility.
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Motilin
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Gastrointestinal Secretions 7 l of fluid are secreted per day plus 2 liters ingested. Only 100 ml excreted in feces so 8.9 l are absorbed and reabsorbed per day. Enzymes Mucus Water and electrolytes (Na + , Cl - , K + ) HCL (stomach) • HCO 3 - (salivary glands, pancreas, intestine, stomach)
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9 liters = 2 gallons
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PGY300lec2GI - Regulation of Gastrointestinal Functions Dr...

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