PGY300lec4 copy

PGY300lec4 copy - Physiology of the Stomach Silverthorn...

Info iconThis preview shows pages 1–15. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Physiology of the Stomach Silverthorn pages 702-705 Dr. John A. Krasney Gastrointestinal Endoscopy • Gastroscopy • http://www.gastrointestinalatlas.com/index. html Pylorus Rugae Functions of the Stomach • Food storage-reservoir function- plasticity, receptive relaxation • Digestion : Mechanical- peristalsis, churning, retropulsion. Chemical- protein digestion by acid and proteolytic enzymes, fat digestion by gastric lipase, no carbohydrate digestion (salivary amylase is inactivated at low pH). Functions of the Stomach (cont.) • Absorption of lipid soluble substances including alcohol and aspirin. • Protection against bacteria (HCl) and autodigestion. • Secretion of intrinsic factor that allows for absorption of vitamin B12 in ileum. Parietal cells Mucus cells Chief cells Na K The Parietal Cell (Oxyntic Cell) • Proton pump (million-fold H + gradient from cell at pH 7.2 to gastric lumen at pH 1.0). Requires O 2 and hydrolysis of ATP. • Carbonic anhydrase (C.A.): C.A. C.A. CO 2 + H 2 O ⇔ H 2 CO 3 ⇔ H + + HCO 3- The Parietal Cell (cont.) H + is secreted into the gastric lumen in exchange for K +. • HCO 3- is reabsorbed into blood in exchange for Cl- . Reabsorbed HCO 3- generates the Alkaline Tide ....
View Full Document

This note was uploaded on 01/10/2010 for the course PGY 300 taught by Professor Krasney during the Fall '05 term at SUNY Buffalo.

Page1 / 36

PGY300lec4 copy - Physiology of the Stomach Silverthorn...

This preview shows document pages 1 - 15. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online