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PGY300lec5 copy - PANCREAS AND LIVER Silverthorn pages...

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PANCREAS AND LIVER Silverthorn pages 685-689 Dr John A. Krasney
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Pancreas Endocrine Functions : Secretion of insulin and glucagon (reviewed in Endocrine Section of Course). Exocrine Functions : Acinar cells secrete inactive zymogens or proenzymes that are activated in the intestine. Duct cells secrete a serous, HCO 3 - rich solution. Pancreatic juice is isoosmotic to plasma.
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Acinar Cell Secretions Pancreatic Amylase (active) Prolipases ( inactive zymogens) Proenzyme proteases ( inactive zymogens): Trypsinogen Chymotrypsinogen Secretion of zymogens protects pancreas from autodigestion.
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H 3 -labeled amino acids
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Acinar Cell Secretagogues Cholecystokinin (CCK) from I cells in duodenum (stimulus is fat, peptides, amino acids). Acetylcholine from vagus nerve (neural). Secretin from S cells in duodenum (H + is stimulus for secretion). Vasoactive intestinal peptide (VIP). CCK is most potent acinar secretagogue . Synergy exists among secretagogues.
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Acinar Cell Secretion Ca ++ is required for secretion. 20 proteins are synthesized and released. Trypsinogen is cleaved by intestinal enteropeptidase to become Trypsin which is proteolytic. Trypsin then cleaves other proenzymes to activate them. Acinar cell also secretes isotonic NaCl solution.
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Pancreatic Duct Cell Na K Na HCO 3 - HCO 3 - CO 2 K Na H + CO 2 + H 2 O CA H + + HCO 3 - HCO 3 - Cl - Acinar Cells Proteins, NaCl Cl
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PGY300lec5 copy - PANCREAS AND LIVER Silverthorn pages...

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