PGY300Renallec2

PGY300Renallec2 - GLOMERULAR FILTRATION PHYSIOLOGY 300 DR...

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GLOMERULAR FILTRATION PHYSIOLOGY 300 DR JOHN A. KRASNEY
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Reading Chapter 19, pages 620-625 Animations: Anatomy Review pages 10-21 Glomerular Filtration pages 1-16.
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Renal Blood Flow The kidneys receive a very high blood flow, 25% of the cardiac output or about 1300- 1500 ml/ minute for both kidneys. The high blood flow is associated with the evolution of the kidneys as filtering organs.
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Renal Oxygen Consumption The kidneys have a very high oxygen consumption. This is due to the high energy cost of reabsorbing sodium.
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Vasomotor Activity Assuming arterial pressure is constant: Arteriolar Vasoconstriction- contraction of arteriolar smooth muscle increases vascular resistance and pressure downstream decreases. Arteriolar Vasodilation- relaxation of arteriolar smooth muscle decreases vascular resistance and pressure downstream increases.
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Glomerular Capillary Pressure Hydrostatic pressure in the glomerulus is due to: Arterial pressure Vasomotor tone in the Afferent arteriole. Vasomotor tone in the Efferent arteriole. Glomerular capillary pressure is rather high, about 50-60 mm Hg.
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Three sieves in series: Capillary endothelium (negative charge). Basal Lamina
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PGY300Renallec2 - GLOMERULAR FILTRATION PHYSIOLOGY 300 DR...

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