1. Midterm 1 Version A

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Unformatted text preview: York
BIOL
2040
Fall
2009
 
 Kelly
Midterm
1A
Oct
 Biology 2040 Midterm I Version A Oct. 9, 2009 / 8:30 – 9:20 am • This exam must be submitted with your scantron sheet to receive a grade. • Your student number and name must be CLEARLY written on this booklet and scantron sheet in order to receive a grade. • Your student number must be BUBBLED CORRECTLY on the scantron to receive a grade • All questions on this exam are multiple choice – there is NO pattern to the answers (e.g., c, a, b, b, a, d), so donʼt look for one! • Non-programmable calculators are PERMITTED. • If you complete the exam before the allotted time, raise your hand to identify yourself to the invigilator. • The invigilators and instructors will immediately RELOCATE anyone or SUSPEND the examination for any individuals who are suspected of academic dishonesty. Good Luck! Last name First Name Student Number York
BIOL
2040
Fall
2009
 
 Kelly
Midterm
1A
Oct
 Section
A:
Answer
the
following
by
filling
in
the
appropriate
response
on
your
scantron.
 1. You
have
midterm
version
A.
Fill
in
a
for
this
question!
 
 2. Which
of
the
following
doesn’t
have
to
be
a
characteristic
of
a
good
model
organism?
 A. Short
generation
time
that
allows
multiple
generations
to
be
examined
within
a
short
time.
 B. Produce
large
numbers
of
offspring.
 C. Possess
a
genome
that
is
closely
related
to
the
human
genome.
 D. Only
a
and
b
are
not
characteristics
of
a
model
organism.
 
 3. An
example
of
a
discrete
trait
is:
 A. Pea
colour
 B. Height
in
humans
 C. Skin
pigmentation
 D. Any
trait
that
exhibits
quantitative
variation.
 
 4. Organisms
with
the
same
genotype
may
show
different
phenotypes
because
of:
 A. Nonfunctional
genes
in
some
individuals.
 B. Environmental
factors,
such
as
nutrition.
 C. Modifier
genes.
 D. Both
A
and
C.
 E. Both
B
and
C.
 
 5. What
information
cannot
be
obtained
from
an
individual’s
karyotype?
 A. The
ploidy
of
the
individual.
 B. The
types
of
chromosomes
present
in
the
individual.
 C. The
number
of
autosomes
in
the
individual.
 D. The
specific
gene
that
causes
a
genetic
disorder

 
 6. Which
aspect
of
chromosome
behaviour
most
clearly
accounts
for
Mendel’s
principle
of
segregation?
 A. Movement
of
sister
chromatids
to
opposite
poles
at
anaphase
II
of
meiosis.
 B. Movement
of
homologous
chromosomes
to
opposite
poles
at
anaphase
I
of
meiosis.
 C. Crossing
over
between
homologous
chromosomes
during
prophase
I
of
meiosis.
 D. Independent
alignment
of
different
homologous
pairs
during
metaphase
I.
 
 7. The
 somatic
 cells
 of
 males
 in
 the
 species
 Dragontis
 elementis
 contain
 only
 1
 pair
 of
 homologous
 chromosomes
 (R1
 and
 R2),
 and
 another
 chromosome
 without
 a
 homolog
 (chromosome
 M).
 Which
 chromosomal
combinations
are
most
likely
to
be
among
the
4
meiotic
products
from
a
single
cell?
 A. R1M,
R1M,
R2,
R2
 B. R1M,
R2M,
R1,
R2
 C. R1M,
R1M,
R2M,
R2M
 D. R1R1,
R2R2,
M,
M
 
 
 
 
 
 York
BIOL
2040
Fall
2009
 
 Kelly
Midterm
1A
Oct
 8. Genes
 L
 &
 W
 are
 located
 on
 different
 chromosomes.
 
 A
 woman
 is
 heterozygous
 for
 both
 genes.

 Which
of
the
following
processes
would
generate
different
combinations
of
alleles
of
these
2
genes?
 A. Recombination
 B. Independent
assortment
 C. Sister
chromatid
segregation

 D. Segregation
 
 9. Muscular
dystrophy
(d)
is
an
X‐linked
disorder.

George
is
affected
with
muscular
dystrophy
and
will
 therefore
pass
the
disease
allele
on
to
 A. All
of
his
daughters.
 B. All
of
his
sons.
 C. Half
of
his
sons,
and
half
of
his
daughters.
 D. All
of
his
sons
and
daughters.
 
 Below
 is
 a
 pedigree
 for
 the
 ability
 to
 become
 invisible
 and
 applies
 to
 the
 next
 2
 questions.
 
 Shaded
 symbols
 represent
 individuals
 that
 exhibit
 the
 ability
 to
 become
 invisible.
 
 Assume
 that
 invisibility
 is
 completely
penetrant.
Individuals
III‐1
and
III‐2
are
fraternal
(non‐identical)
twins.


 
 I 
 
 II 
 
 III 
 
 
 10. For
the
above
pedigree,
what
is
the
mode
of
inheritance
of
invisibility?
 A. Autosomal
recessive
 B. Autosomal
dominant
 C. X‐linked
recessive
 D. X‐linked
dominant
 
 11. What
is
the
probability
that
the
first‐born
twin
in
generation
III
will
be
able
to
become
invisible?
 A. 1/2
 B. 1/3
 C. 1/4
 D. 1/6
 
 12. Priya
is
a
carrier
for
the
autosomal
recessive
disease
cystic
fibrosis
(Tt)
and
is
also
a
carrier
for
the
X‐ linked
disease
 hemophilia
(XHXh).

Priya
produces
an
egg
that
has
the
 T
allele
and
the
 H
and
 h
alleles
 of
the
cystic
fibrosis
gene.

Assuming
no
crossing
over,
what
can
you
conclude?
 A. The
gamete
has
a
normal
chromosomal
number.
 B. A
nondisjunction
event
occurred
in
Meiosis
I.
 C. A
nondisjunction
event
occurred
in
Meiosis
II.
 D. A
nondisjunction
event
occurred,
but
you
can’t
determine
when
it
occurred
during
meiosis.
 
 
 
 York
BIOL
2040
Fall
2009
 
 Kelly
Midterm
1A
Oct
 13. What
 is
 the
 probability
 that
 a
 gamete
 from
 an
 individual
 with
 the
 genotype
 Q1Q2R1R1S1S2
 will
 contain
all
paternally
derived
homologues?
 A. 1/6
 B. 1/3
 C. 1/4
 D. 1/8
 
 14. Kroots
 have
 a
 diploid
 chromosome
 number
 of
 6.
 How
 many
 different
 chromosome
 combinations
 can
normally
be
found
in
the
gametes
of
this
organism,
assuming
that
no
crossing
over
occurs?
 A. 2
 B. 4
 C. 6
 D. 8
 
 15. Scaly
knuckles
is
a
 rare
 autosomal
 dominant
condition
in
humans
that
is
only
80%
 penetrant.
What
 is
the
probability
that
a
child
born
to
a
father
known
not
to
carry
the
mutation
and
a
mother
 with
 scaly
knuckles
will
have
the
condition?
 A. 0.8
 B. 0.5
 C. 0.4
 D. 0.2
 
 16. Keritinosis
(k)
is
a
recessive
disorder
that
causes
dry
skin.

A
family
with
a
history
of
keritinosis
has
7
 KK
 individuals
 and
5
 Kk
individuals
 –
all
have
the
normal
phenotype.
7
individuals
have
the
genotype
 kk.
Of
individuals
with
 kk,
2
have
dry
hands,
3
have
dry
hands
and
dry
feet,
and
2
are
normal.

This
is
 an
example
of
which
of
the
following?
 A. Variable
expressivity
 B. Incomplete
dominance
 C. Incomplete
penetrance
 D. Both
a
and
b
 E. Both
a
and
c
 
 17. The
 grey‐lethal
 mutation
 in
 mice
 is
 known
 to
 affect
 coat
 colour,
 and
 causes
 the
 bone
 disorder
 osteoporosis.
This
is
an
example
of

 A. High
penetrance
 B. Epistasis
 C. High
expressivity D. Pleiotropy
 E. Incomplete
dominance
 
 18. Which
 of
 the
 following
 pedigrees
 illustrates
 complementation?
Shaded
symbols
represent
affected
individuals.
 A. A
 B. B
 C. C
 D. D
 York
BIOL
2040
Fall
2009
 
 Kelly
Midterm
1A
Oct
 
 19. You
 have
 identified
 three
 inbred
 mutant
 dragons
 (named
 strain
 A,
 B,
 and
 C)
 that
 have
 an
 orange
 coat
 colour
instead
of
the
wild‐type
greenish‐brown.

These
dragons
were
crossed
to
each
other
and
 it
was
found
that
when
strain
A
and
C
were
crossed,
the
F1
was
orange;
when
A
and
B
were
crossed,
 the
 progeny
 were
 all
 greenish‐brown;
 and
 when
 B
 and
 C
 were
 crossed,
 the
 progeny
 were
 all
 greenish‐brown.

What
is
the
best
explanation
for
this?
 A. A
and
B
have
mutations
in
the
same
gene,
and
C
has
a
mutation
in
a
different
gene.
 B. A
and
C
have
mutations
in
the
same
gene,
and
B
has
a
mutation
in
a
different
gene.
 C. B
and
C
have
mutations
in
the
same
gene,
and
A
has
a
mutation
in
a
different
gene.
 D. A,
B
and
C
are
all
mutations
in
different
genes.
 E. A,
B
and
C
are
all
mutations
in
the
same
gene.
 
 20. The
 genes
 IA,
 IB
 and
 i
 contribute
 to
 the
 ABO
 blood
 antigens
 in
 humans.
 In
 another
 trait,
 Rh+
 is
 dominant
to
Rh‐.
If
a
mother
with
phenotype
A
Rh+
has
a
child
with
a
phenotype
of
O
Rh+,
which
one
 of
the
following
genotypes
is
not
possible
for
the
father?
 A. IAi
Rh‐Rh‐
 B. IBi
Rh+Rh‐
 C. ii
Rh‐Rh‐
 D. ii
Rh+Rh‐
 E. IAIA
Rh+Rh+
 
 21. Mark
 is
 a
 carrier
 for
 diastrophic
 dysplasia
 (Dd),
 an
 autosomal
 recessive
 disorder
 and
 has
 achrondroplasia,
which
is
an
autosomal
dominant
trait
(Aa).

Dustina
is
also
a
carrier
for
diastrophic
 dysplasia
and
also
has
achrondroplasia.

 AA
human
embryos
do
not
survive
beyond
the
first
few
cell
 divisions
and
the
allele
is
considered
recessive
lethal.

Mark
and
Dustina
want
to
have
a
child.
What
is
 the
probability
that
their
first‐born
child
will
have
only
diastrophic
dysplasia?
 A. 0
 B. 1/4
 C. 1/6
 D. 1/12
 E. 1/16
 
 22. The
allele
for
eye
 colour
is
located
on
the
X‐chromosome
in
Drosophila;
white
eyes
are
recessive.

 Vestigial
wings
(short,
stubby
wings)
are
recessive
and
the
gene
is
located
 on
an
 autosome.

Sex
is
 determined
genetically
in
fruit
flies,
as
in
humans
and
males
are
the
heterogametic
sex.

You
have
a
 white‐eyed
male
fruit
fly
with
vestigial
wings
and
a
wild‐type
female
known
to
be
heterozygous
for
 both
traits.
What
is
the
probability
that
these
two
flies
will
generate
a
female
offspring
with
vestigial
 wings
and
white
eyes?
 A. 1/2
 B. 1/4
 C. 1/8
 D. 1/16
 E. none
 
 York
BIOL
2040
Fall
2009
 
 Kelly
Midterm
1A
Oct
 
 23. In
 Smurfs,
 the
 allele
 for
 pigment
 (P)
 is
 dominant
 to
 no
 pigment
 (p)
 and
 the
 allele
 for
 blue
 (B)
 is
 dominant
to
the
allele
for
white
(b).
If
the
pigment
allele
(P)
is
absent,
there
is
no
pigment,
regardless
 of
which
blue
allele
is
present
and
the
Smurfs
are
white.

How
many
white
Smurfs
will
be
present
in
 the
F2
of
a
cross
between
a
true‐breeding
blue
Smurf
and
a
white
Smurf
that
is
homozygous
recessive
 for
both
genes?
 A. 1/16
 B. 3/16
 C. 4/16
 D. 7/16
 E. 9/16
 
 
 Section
B:
Answer
the
following
by
filling
in
the
blank
with
the
appropriate
response.
 
 24. The
β‐globin
gene
has
many
alleles.

What
is
the
total
number
of
different
alleles
of
the
β‐globin
 gene
that
could
be
carried
by
6
children
with
the
same
mom
&
dad.
______
 
 25. A
human
somatic
cell
contains
approximately
13
 picograms
(pg)
of
DNA
in
the
G1
phase.

How
any
 picograms
of
DNA
are
expected
in
a
gamete
produced
by
this
individual?
_____
pg
 
 26. Two
 individuals
 of
 genotype
 AABBCCDD
 and
 aabbccdd
 are
 mated.
 The
 F1
 generation
 is
 interbred
 (self‐fertilized)
 to
 yield
 3000
 progeny.
 
 What
 proportion
 of
 the
 F2
 is
 expected
 to
 be
 AabbCcDD?

 ______________
 
 27. Tasha
 and
 Dimitri
 are
 both
 carriers
 of
 the
 autosomal
 recessive
 condition
 halitosis.
 If
 they
 have
 3
 children,
what
is
that
probability
that
one
will
be
affected
and
two
will
not,
regardless
of
order?
____
 
 
 
 ...
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