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LEARNING OBJECTIVES Use the following learning objectives to guide your reading and studying of the material for BIOL 2040. Ch. 8 (section 8.6) After reading Chapter 5 you should be able to: Describe, in general terms, how a gene encodes for a protein product. Describe, in general terms how a mutation that changes 1 or many nucleotide pairs of DNA may modify any of the steps or products of gene expression. Define the following mutations and their effects: silent, missense, nonsense, frameshift. Explain how a mutation in a gene, but not in the coding region, could alter gene expression. Explain why most loss‐of‐function mutations are recessive. Explain why most gain‐of‐function mutations are dominant. Define the following mutations and their potential effects: null (amorphic) mutations, hypomorphic mutations, dominant negative (antimorphic) mutations, hypermorphic mutations, neomorphic mutations, as well as haploinsufficiency ad ectopic expression. Recognize, given a scenario, the different types of mutations, including loss/gain of function
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This note was uploaded on 01/10/2010 for the course BIOLOGY biol2040 taught by Professor Tamarakelly during the Fall '09 term at York University.

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