3. Transcription_Translation_Review_on_own

3. Transcription_Translation_Review_on_own - 11/22/09
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Unformatted text preview: 11/22/09
 Nov 16th •  You
have
a
muta0on
in
a
gene
that
encodes
for
a
protein
involved
in
 the
gene
expression
machinery
of
the
cell.
What
effects
would
you
 predict?
 1.  2.  3.  4.  5.  No
effect,
there
are
other
enzymes
to
pick
up
the
slack.
 It
affects
just
one
gene.
 It
affects
just
a
few
genes.
 It
affects
many
genes.
 It
affects
all
genes.
 • To
review
on
your
own
 1
 11/22/09
 •  If
you
can’t
remember
transcrip0on
–
you
should
take
a
look
at
Ch.
8,
Sec0on
 8.2
(p265
‐274)
–
see
learning
objec0ves
below;
 •  If
you
can’t
remember
transla0on
–
you
should
look
at
Ch.
8.3
(275
‐
 •  Describe,
in
general,
the
steps
of
transcrip0on
&
the
purpose
of
 transcrip0on.
 •  Define:
promoter,
RNA
polymerase,
terminator,
reverse
transcriptae,
 primary
transcript,
methylated
cap/poly‐A
tail.
 •  Explain
what
RNA
splicing
does.
 •  Explain
what
alterna0ve
splicing
does.
 •  Describe
what
is
meant
by
the
wobble.
 •  Describe
how
the
wobble
impacts
muta0onal
events
&
their
effects
on
 phenotype.
 •  Describe
the
effect
of
a
muta0on
in
a
ribosomal
gene.
 •  Describe
the
purpose
of
transla0on
&
the
general
steps
involved.
 •  Describe
what
is
meant
by
post‐transla0onal
modifica0on.
 2
 11/22/09
 3
 11/22/09
 4
 11/22/09
 5
 11/22/09
 • You
should
know
the
preceding
informa0on
well
enough
to
 fulfill
the
learning
objec0ves.
 6
 ...
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This note was uploaded on 01/10/2010 for the course BIOLOGY biol2040 taught by Professor Tamarakelly during the Fall '09 term at York University.

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