6. Ch14_Dec_2_ - 11/29/09...

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11/29/09 1 All you wanted to know about transposable elements… A gene that causes chromosome breakage 130 Identification of broken chromosomes: effects on phenotype Transposable Elements Unusual feature of the Ds locus Causes mutaBon AcBon appeared to require presence of another allele, Ac (acBvator) AcBvator couldn’t be mapped (appeared to be in diFerent posiBon in diFerent maize lines) 131
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11/29/09 2 Discovery of unstable alleles 132 Explaining the results: Ds was TRANSPOSABLE 134
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11/29/09 3 Ac ALSO jumped around! Ac was mapped to different locations in different individuals Impossible to get a consistent map location Ac could also be located in the original position of Ds & cause chromosome breaks 135 Conclusions from McClintock’s Experiments Some ‘genes’ can change their position McClintock called this transposition These transposable elements (TE) can both transpose, thereby causing insertions & deletions, as well as causing chromosome breaks Some TEs can move on their own (autonomous), while others require presence of another element to transpose (non-autonomous) 136
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This note was uploaded on 01/10/2010 for the course BIOLOGY biol2040 taught by Professor Tamarakelly during the Fall '09 term at York University.

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6. Ch14_Dec_2_ - 11/29/09...

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