8. Ch5_Nov_2_ - 11/3/09
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Unformatted text preview: 11/3/09
 Mito,c
Recombina,on
&
Disease
 • Recombina,on
during
mitosis

shouldn’t
happen
 114
 Mito,c
Recombina,on
&
Disease
 • Recombina,on
during
mitosis

shouldn’t
happen
 115
 1
 11/3/09
 Mito,c
Recombina,on
&
Disease
 • Can
use
model
organisms
to
examine
in
more
detail
 • Or
exploit
for
research
purposes
 ADE ADE ADE ade ade ADE ade ade ADE WHITE ade RED! 116
 Mito,c
Recombina,on
&
Disease
 • Knudson’s
2
Hit
Hypothesis
 • In
order
to
display
cancer
that
involves
non‐func,oning
TSG,
must
 have
2
hits

1
to
each
allele
 • E.g.,
re,noblastoma
 • 1/20
000
live
births

gene,c
predisposi,on
 • Born
with
only
1
func,onal
copy
of
the
Rb
gene
 • Rb+
gene

normal
state
 • Tumour
suppressor
gene
(TSG)
 • If
both
copies
non‐func,onal

tumour
develops
 117
 2
 11/3/09
 Mito,c
Recombina,on
&
Disease
 • Knudson’s
2
Hit
Hypothesis
 • In
order
to
display
cancer
that
involves
non‐func,oning
TSG,
must
 have
2
hits

1
to
each
allele
 • Sporadic
Re,noblastoma
 • 60%
cases
 • Strikes
older
age
 • Need
2
hits
 • Inherited
Re,noblastoma
 • 40%
cases
 • Strikes
younger
age
 • Need
only
1
hit
 • Inherited
gene,c
 predisposi,on
 118
 Mito,c
Recombina,on
&
Disease
 • Knudson’s
2
Hit
Hypothesis
 • In
order
to
display
cancer
that
involves
non‐func,oning
TSG,
must
 have
2
hits

1
to
each
allele
 119
 3
 ...
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This note was uploaded on 01/10/2010 for the course BIOLOGY biol2040 taught by Professor Tamarakelly during the Fall '09 term at York University.

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